Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1
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چکیده
منابع مشابه
Caveolin-1 Protects B6129 Mice against Helicobacter pylori Gastritis
Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is frequently down-regulated. However, the function of Cav1 in H. pylori infection and pathogenesis of GC remained unknown. We show here that Cav...
متن کاملA genetic basis for atrophy: dominant nonresponsiveness and Helicobacter-induced gastritis in F1 hybrid mice.
BACKGROUND The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. AIMS To investigate these host factors further by using genetic crosses of responder and non-responder mice. METHODS F(1) hybrids of the non-...
متن کاملLoss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1
Thioredoxin-1 (Trx1) protects the heart from ischemia/reperfusion (I/R) injury. Given that the age at which the first episode of coronary disease takes place has considerably decreased, life at middle-aged (MA) emerges as a new field of study. The aim was determine whether infarct size, Trx1 expression and activity, Akt and GSK-3β were altered in young (Y) and MA mice overexpressing cardiac Trx...
متن کاملA genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice
Background—The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. Aims—To investigate these host factors further by using genetic crosses of responder and non-responder mice. Methods—F1 hybrids of the nonrespond...
متن کاملInvolvement of cyclooxygenase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice.
BACKGROUND AND AIMS The hyperplastic changes observed in Helicobacter pylori-associated gastritis have been considered to increase the risk of gastric cancer. The aim of this study was to determine whether cyclooxygenase-2 is involved in the hyperplastic changes in mice infected with H. pylori. METHODS Seven-week-old, male C57BL/6 mice (n=40) were inoculated with the Sydney strain of H. pylor...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2005
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3700305